Rationale: Deep brain stimulation (DBS) of the hippocampus is proposed for enhancement of memory impaired by injury or disease. Many pre-clinical DBS paradigms can be addressed in epilepsy patients undergoing intracranial monitoring for seizure localization, since they already have electrodes implanted in brain areas of interest. Even though epilepsy is usually not a memory disorder targeted by DBS, the studies can nevertheless model other memory-impacting disorders, such as Traumatic Brain Injury (TBI). Methods: Human patients undergoing Phase II invasive monitoring for (...) intractable epilepsy were implanted with depth electrodes capable of recording neurophysiological signals. Subjects performed a delayed-match-to-sample (DMS) memory task while hippocampal ensembles from CA1 and CA3 cell layers were recorded to estimate a multi-input, multi-output (MIMO) model of CA3-to-CA1 neural encoding and a memory decoding model (MDM) to decode memory information from CA3 and CA1 neuronal signals. After model estimation, subjects again performed the DMS task while either MIMO-based or MDM-based patterned stimulation was delivered to CA1 electrode sites during the encoding phase of the DMS trials. Each subject was sorted (post hoc) by prior experience of repeated and/or mild-to-moderate brain injury (RMBI), TBI, or no history (control) and scored for percentage successful delayed recognition (DR) recall on stimulated vs. non-stimulated DMS trials. The subject’s medical history was unknown to the experimenters until after individual subject memory retention results were scored. Results: When examined compared to control subjects, both TBI and RMBI subjects showed increased memory retention in response to both MIMO and MDM-based hippocampal stimulation. Furthermore, effects of stimulation were also greater in subjects who were evaluated as having pre-existing mild-to-moderate memory impairment. Conclusion: These results show that hippocampal stimulation for memory facilitation was more beneficial for subjects who had previously suffered a brain injury (other than epilepsy), compared to control (epilepsy) subjects who had not suffered a brain injury. This study demonstrates that the epilepsy/intracranial recording model can be extended to test the ability of DBS to restore memory function in subjects who previously suffered a brain injury other than epilepsy, and support further investigation into the beneficial effect of DBS in TBI patients. (shrink)

In his What is Business Ethics? Peter Drucker accuses business ethics of singling out business unfairly for special ethical treatment, of subordinating ethical to political concerns, and of being, not ethics at all, but ethical chic. We contend that Drucker's denunciation of business ethics rests upon a fundamental misunderstanding of the field. This article is a response to his charges and an effort to clarify the nature, scope and purpose of business ethics.

In the preface to this book Stephen Toulmin recalls how Wittgenstein's later work appeared to his English students "as unique and extraordinary as the Tractatus had appeared to Moore." "Meanwhile," he recalls, "for our own part, we struck Wittgenstein as intolerably stupid, and he was sometimes in despair about getting us to grasp what he was talking about." Toulmin suggests that this "mutual incomprehension" was due to a "culture clash: the clash between a Viennese thinker whose whole mind had (...) been formed in a post-Kantian environment, and an audience of students who came to him with attitudes and preoccupations shaped by the neo-Humean empiricism of Moore, Russell and their associates." Engel's book is meant primarily to show that Wittgenstein's thought grows out of the Kantian philosophy, but not that it is simply derived from Kant. Rather, according to Engel, Wittgenstein was the first to see the full value of the insights of Kant and Schopenhauer. Engel bases his argument on the Blue Book. According to Engel the argument of the Blue Book comprehends two divergent theories of the origin of metaphysics. These two theories are represented in Engel's book by Ayer and Lazerowitz. For Ayer metaphysics is grounded in the inherently deceptive character of language; and the way to overcome metaphysics is but to be attentive to language. Lazerowitz, on the other hand, attempts to explain why it is that language is deceptive. Lazerowitz's argument as presented by Engel requires as a premise the proposition that the deceptions of language are not that intrinsically difficult to see through, or that metaphysical arguments are obviously "innovations." And therefore the origin of metaphysics must be sought outside of the structure of language. Lazerowitz locates the root of metaphysics in the passions, specifically, in fear--in the fear of change which is ultimately the fear of death. Engel sees each of these positions as in its way legitimate but essentially partial. Wittgenstein's thought is thus more profound than that which is derived from it. It is precisely this awareness of the necessity for both kinds of explanation that Wittgenstein, according to Engel, inherited from the tradition of Kantian metaphysics: in the first Critique's seeking both to account for the impossibility of metaphysics while, at the same time, arguing for the necessity of metaphysics as a natural disposition or arguing for the necessity of a "will to metaphysics." While Engel's argument is not as clear or thorough as it ought to be, his thesis, that Wittgenstein's work is not simply a "repudiation of our philosophical tradition, but rather is its proper twentieth-century continuation," is--in the main--convincing. The book is worth reading.--J. W. S. (shrink)

It is nearly 10 years since Patrick Haggard and colleagues first reported the ‘intentional binding’ effect . The intentional binding effect refers to the subjective compression of the temporal interval between a voluntary action and its external sensory consequence. Since the first report, considerable interest has been generated and a fascinating array of studies has accumulated. Much of the interest in intentional binding comes from the promise to shed light on human agency. In this review we survey studies on intentional (...) binding, focusing, in particular, on the link between intentional binding and the sense of agency . We suggest that, whilst it is yet to be fully explicated, the link between intentional binding and the sense of agency is compelling. We conclude by considering outstanding questions and future directions for research on intentional binding. (shrink)

Unmet legal needs contribute to housing, income, and food insecurity, along with other conditions that harm health and drive health inequity. Addressing health injustice requires new tools for the next generations of lawyers, doctors, and other healthcare professionals. An interprofessional group of co-authors argue that law and medical schools and other university partners should develop and cultivate Academic Medical-Legal Partnerships (A-MLPs), which are uniquely positioned to leverage service, education, and research resources, to advance health justice.

This essay constitutes an attempt to probe the very idea of a saying/showing distinction of the kind that Wittgenstein advances in the Tractatus—to say what such a distinction consists in, to say what philosophical work it has to do, and to say how we might be justified in drawing such a distinction. Towards the end of the essay the discussion is related to Wittgenstein’s later work. It is argued that we can profitably see this work in such a way that (...) a saying/showing distinction arises there too. In particular, in the final sub-section of the essay, it is suggested that we can see in Wittgenstein’s later work an inducement to say what we are shown. (shrink)

In this bold and innovative new work, A.W. Moore poses the question of whether it is possible for ethical thinking to be grounded in pure reason. In order to understand and answer this question, he takes a refreshing and challenging look at Kant’s moral and religious philosophy. Identifying three Kantian Themes – morality, freedom and religion – and presenting variations on each of these themes in turn, Moore concedes that there are difficulties with the Kantian view that morality (...) can be governed by ‘pure’ reason. He does however defend a closely related view involving a notion of reason as socially and culturally conditioned. In the course of doing this, Moore considers in detail, ideas at the heart of Kant’s thought, such as the categorical imperative, free will, evil, hope, eternal life and God. He also makes creative use of the ideas in contemporary philosophy, both within the analytic tradition and outside it, such as ‘thick’ ethical concepts, forms of life and ‘becoming those that we are’. Throughout the book, a guiding precept is that to be rational is to make sense, and that nothing is of greater value to use than making sense. (shrink)

We investigate the processes underlying the feeling of control over one’s actions . Sense of agency may depend on internal motoric signals, and general inferences about external events. We used priming to modulate the sense of agency for voluntary and involuntary movements, by modifying the content of conscious thought prior to moving. Trials began with the presentation of one of two supraliminal primes, which corresponded to the effect of a voluntary action participants subsequently made. The perceived interval between movement and (...) effect was used as an implicit measure of sense of agency. Primes modulated perceived intervals for both voluntary and involuntary movements, but the modulation was greatest for involuntary movements. A second experiment showed that this modulation depended on prime–movement contiguity. We propose that sense of agency is based on a combination of internal motoric signals and external sensory evidence about the source of actions and effects. (shrink)

This book is concerned with the history of metaphysics since Descartes. Taking as its definition of metaphysics 'the most general attempt to make sense of things', it charts the evolution of this enterprise through various competing conceptions of its possibility, scope, and limits. The book is divided into three parts, dealing respectively with the early modern period, the late modern period in the analytic tradition, and the late modern period in non-analytic traditions. In its unusually wide range, A. W. (...) class='Hi'>Moore's study refutes the tired old cliché that there is some unbridgeable gulf between analytic philosophy and philosophy of other kinds. It also advances its own distinctive and compelling conception of what metaphysics is and why it matters. Moore explores how metaphysics can help us to cope with continually changing demands on our humanity by making sense of things in ways that are radically new. (shrink)

The experience of causation is a pervasive product of the human mind. Moreover, the experience of causing an event alters subjective time: actions are perceived as temporally shifted towards their effects [Haggard, P., Clark, S., & Kalogeras, J.. Voluntary action and conscious awareness. Nature Neuroscience, 5, 382-385]. This temporal shift depends partly on advance prediction of the effects of action, and partly on inferential "postdictive" explanations of sensory effects of action. We investigated whether a single factor of statistical contingency could (...) explain both these aspects of causal experience. We studied the time at which people perceived a simple manual action to occur, when statistical contingency indicated a causal relation between action and effect, and when no such relation was indicated. Both predictive and inferential "postdictive" shifts in the time of action depended on strong contingency between action and effect. The experience of agency involves a process of causal learning based on statistical contingency. (shrink)

In Michael Dummett's celebrated essay on Gödel's theorem he considers the threat posed by the theorem to the idea that meaning is use and argues that this threat can be annulled. In my essay I try to show that the threat is even less serious than Dummett makes it out to be. Dummett argues, in effect, that Gödel's theorem does not prevent us from "capturing" the truths of arithmetic; I argue that the idea that meaning is use does not require (...) that we be able to "capture" these truths anyway. Towards the end of my essay I relate what I have been arguing first to Dummett's concept of indefinite extensibility and then to some of Wittgenstein's remarks on Gödel's theorem. (shrink)

In this essay I consider the argument that Bernard Williams advances in ‘The Makropolus Case’ for the meaninglessness of immortality. I also consider various counter-arguments. I suggest that the more clearly these counter-arguments are targeted at the spirit of Williams's argument, rather than at its letter, the less clearly they pose a threat to it. I then turn to Nietzsche, whose views about the eternal recurrence might appear to make him an opponent of Williams. I argue that, properly interpreted, these (...) views in fact make him an ally. (shrink)

The philosophy of mathematics was of colossal importance to Wittgenstein. Its problems had a peculiarly strong hold on him; and he seems to have thought that it was in addressing these problems that he produced his greatest work. However robust the distinction between the calculus and the surrounding prose, the prose may infect the calculus; or the prose may infect how we couch the calculus. Yet Wittgenstein's writings in the philosophy of mathematics stand in a curious relation to this self‐assessment. (...) By 1938, he had written an early version of his master‐work Philosophical Investigations, the second half of which was on the philosophy of mathematics. This material did not survive into the version of Philosophical Investigations that was eventually published after his death. Instead it appeared, modified in various ways, along with notes that he wrote during World War II, as Remarks on the Foundations of Mathematics, another posthumous publication, assembled by his literary executors. (shrink)

The paper builds on the postulate of “myths we live by,” which shape our imaginative life (and hence our social expectations), but which are also open to reflective study and reinvention. It applies this principle, in particular, to the concepts of love and vulnerability. We are accustomed to think of the condition of vulnerability in an objectifying and distancing way, as something that affects the bearers of specific (disadvantaged) social identities. Against this picture, which can serve as a pretext for (...) paternalist and controlling attitudes to the groups in question – notably to women – Anderson urges us to reimagine our vulnerability as a condition not merely of exposure to violence but of openness to mutual affection, love, and friendship. Hegel’s celebrated image of the owl of Minerva, which takes wing only with the coming of dusk, suggests an association of (philosophical) wisdom with negativity – with the experience of death or loss. Anderson, by contrast, proposes an alternative and more hopeful image of the dawn of enlightenment, in the guise of new ethical dispositions shaped by an emancipatory (and so, no longer an oppressive or sexist) conception of our capacity for love. Her main interlocutors or influences in this piece are Judith Butler (who contributes the idea of a “relational ontology”), Michèle Le Doeuff, and Mary Midgley. (shrink)

Kant once wrote, “Many historians of philosophy... let the philosophers speak mere nonsense.... They cannot see beyond what the philosophers actually said to what they really meant to say.’ Rae Langton begins her book with this quotation. She concludes it, after a final pithy summary of the position that she attributes to Kant, with the comment, “That, it seems to me, is what Kant said, and meant to say”. In between are some two hundred pages of admirably clear, tightly argued (...) exegesis, supplemented by detailed references, in which she offers what the dust jacket blurb fairly describes as “a new interpretation and defence of Kant’s doctrine of things in themselves.” This is an extremely engaging and thought-provoking book. I am pleased to recommend it. (shrink)

Anyone who has pondered the limitlessness of space and time, or the endlessness of numbers, or the perfection of God will recognize the special fascination of this question. Adrian Moore's historical study of the infinite covers all its aspects, from the mathematical to the mystical.

In Michael Dummett's celebrated essay on Gödel's theorem he considers the threat posed by the theorem to the idea that meaning is use and argues that this threat can be annulled. In my essay I try to show that the threat is even less serious than Dummett makes it out to be. Dummett argues, in effect, that Gödel's theorem does not prevent us from "capturing" the truths of arithmetic; I argue that the idea that meaning is use does not require (...) that we be able to "capture" these truths anyway. Towards the end of my essay I relate what I have been arguing first to Dummett's concept of indefinite extensibility and then to some of Wittgenstein's remarks on Gödel's theorem. (shrink)

I begin with Kant's notion of a maxim and consider the role which this notion plays in Kant's formulations of the fundamental categorical imperative. This raises the question of what a maxim is, and why there is not the same requirement for resolutions of other kinds to be universalizable. Drawing on Bernard Williams' notion of a thick ethical concept, I proffer an answer to this question which is intended neither in a spirit of simple exegesis nor as a straightforward exercise (...) in moral philosophy but as something that is poised somewhere between the two. My aim is to provide a kind of rational reconstruction of Kant. In the final section of the essay, I argue that this reconstruction, while it manages to salvage something distinctively Kantian, also does justice to the relativism involved in what J. L. Mackie calls 'people's adherence to and participation in different ways of life'. (shrink)

[A. W. Moore] Criteria of ineffability are presented which, it is claimed, preclude the possibility of truths that are ineffable, but not the possibility of other things that are ineffable—not even the possibility of other things that are non-trivially ineffable. Specifically, they do not preclude the possibility of states of understanding that are ineffable. This, it is argued, allows for a reappraisal of the dispute between those who adopt a traditional reading of Wittgenstein’s Tractatus and those who adopt the (...) new reading recently championed by Cora Diamond, James Conant, and others. By maintaining that what the nonsense in the Tractatus is supposed to convey is ineffable understanding, rather than ineffable truth, we can do considerable justice to each of these readings. We can also do considerable justice to the Tractatus. /// [Peter Sullivan] Moore proposes to cut between 'traditional' and 'new' approaches to the Tractatus, suggesting that Wittgenstein's intention is to convey, through the knowing use of nonsense, ineffable understanding. I argue, first, that there is indeed room for a proposal of Moore's general kind. Secondly, though, I question whether Moore's actual proposal is not more in tune with Wittgenstein's later thought than with the attitude of the Tractatus. (shrink)

Language's intentional nature has been highlighted as a crucial feature distinguishing it from other communication systems. Specifically, language is often thought to depend on highly structured intentional action and mutual mindreading by a communicator and recipient. Whilst similar abilities in animals can shed light on the evolution of intentionality, they remain challenging to detect unambiguously. We revisit animal intentional communication and suggest that progress in identifying analogous capacities has been complicated by (i) the assumption that intentional (that is, voluntary) production (...) of communicative acts requires mental-state attribution, and (ii) variation in approaches investigating communication across sensory modalities. To move forward, we argue that a framework fusing research across modalities and species is required. We structure intentional communication into a series of requirements, each of which can be operationalised, investigated empirically, and must be met for purposive, intentionally communicative acts to be demonstrated. Our unified approach helps elucidate the distribution of animal intentional communication and subsequently serves to clarify what is meant by attributions of intentional communication in animals and humans. (shrink)

Background: Freezing of gait is a common symptom in Parkinson’s disease and can be difficult to treat with dopaminergic medications or with deep brain stimulation. Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation delivers current in various frequencies of bursts, while maintaining an intra-burst frequency identical to conventional DBS.Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG.Methods: Ten PD subjects with STN or GPi DBS (...) and complaints of FOG were recruited for this single center, single blinded within-subject crossover study. For each subject, we compared 4, 10, and 15 Hz BCDBS to conventional DBS during the PD medication-OFF state.Results: There were no serious adverse events with BCDBS. It was feasible and straightforward to program BCDBS in the clinic setting. The benefit was comparable to conventional DBS in measures of FOG, functional mobility and in PD motor symptoms. BCDBS had lower battery consumption when compared to conventional DBS.Conclusions: BCDBS was feasible, safe and well tolerated and it has potential to be a viable future DBS programming strategy. (shrink)

This article considers the emergence of world environmental history as a rapidly growing but undertheorized research field. Taking as its central problematic the gap between the fertile theorizations of environmentally-oriented social scientists and the empirically rich studies of world environmental historians, the article argues for a synthesis of theory and history in the study of longue dureesocio-ecological change. This argument proceeds in three steps. First, I offer an ecological reading of Immanuel Wallerstein's The Modern World-System. Wallerstein's handling of the ecological (...) dimensions of the transition from feudalism to capitalism is suggestive of a new approach to world environmental history. Second, I contend that Wallerstein's theoretical insights may be effectively complemented by drawing on Marxist notions of value and above all the concept of “metabolic rift,” which emphasize the importance of productive processes and regional divisions of labor within the modern world-system. Finally, I develop these theoretical discussions in a short environmental history of the two great “commodity frontiers” of early capitalism – the sugar plantation and the silver mining complex. (shrink)

It is only two years since Immanuel Kant published his monumental Critique of Pure Reason.As part of entering into the spirit of this ‘untimely review’, I shall pretend that only the first edition of the Critique exists. This has a bearing on some claims that I shall make about differences between the content of the Prolegomena and that of the Critique. Despite its formidable difficulty, that book has already generated intense interest in the philosophical community. Those who are still struggling (...) to come to terms with its dense and subtle argumentation, or who may not even have started to read it yet but who know from the furore that it has created that it needs to be high on their ‘to read’ list, might easily despair at the prospect of having now to contend with another volume on the same broad range of subjects by the same author. This prospect is not, however, as daunting as it seems. In fact, it should afford some solace, at least if we are to believe claims that Kant makes on beh. (shrink)

This third edition of The Infinite includes a new part 'Infinity Superseded' which contains two new chapters refining Moore's ideas through a re-examination of the ideas of Spinoza, Hegel, and Nietzsche. Much of this is heavily influenced by the work of Deleuze. There is also a new technical appendix on still unresolved issues about different infinite sizes.

This paper explores the relationship between mania, or pathologically elevated mood, and philosophical theories of well-being. A patient, Mr. M., is described who oscillated between periods when he refused medication and periods when he was willing to accept it, and whose desires and life objectives were radically different in his medicated and unmedicated states. The practical dilemmas this raised are explored in terms of the three principal philosophical theories of well-being: hedonism, the desire fulfillment theory, and objectivism. None of these (...) adequately accounted for Mr. M.'s case: hedonism, because pleasure is increased in mildly manic states; desire fulfillment theories, because these suggest that an unending cycle of treatment and nontreatment would be in Mr. M.'s best interests; and objectivism, because, in a form that would be applicable to Mr. M., that theory brings with it substantial risks of paternalism. Four further philosophical approaches are explored briefly—approaches focusing on autonomy, rationality, personal identity, and illness, respectively—but these also provide no straightforward resolution of the clinical dilemmas. It is concluded that philosophical analysis, even if it does not resolve cases like Mr. M.'s, can deepen our understanding of the issues involved in clinical decision making in psychiatry, especially the importance of sensitivity to the patient's wishes and values; and conversely, that mild mania is an important "real life" case against which philosophical theories of well-being can be tested. (shrink)

What can--and what can't--philosophy do? What are its ethical risks--and its possible rewards? How does it differ from science? In Philosophy as a Humanistic Discipline, Bernard Williams addresses these questions and presents a striking vision of philosophy as fundamentally different from science in its aims and methods even though there is still in philosophy "something that counts as getting it right." Written with his distinctive combination of rigor, imagination, depth, and humanism, the book amply demonstrates why Williams was one of (...) the greatest philosophers of the twentieth century. Spanning his career from his first publication to one of his last lectures, the book's previously unpublished or uncollected essays address metaphysics, epistemology, and ethics, as well as the scope and limits of philosophy itself. The essays are unified by Williams's constant concern that philosophy maintain contact with the human problems that animate it in the first place. As the book's editor, A. W. Moore, writes in his introduction, the title essay is "a kind of manifesto for Williams's conception of his own life's work." It is where he most directly asks "what philosophy can and cannot contribute to the project of making sense of things"--answering that what philosophy can best help make sense of is "being human." Philosophy as a Humanistic Discipline is one of three posthumous books by Williams to be published by Princeton University Press. In the Beginning Was the Deed: Realism and Moralism in Political Argument was published in the fall of 2005. The Sense of the Past: Essays in the History of Philosophy is being published shortly after the present volume. (shrink)

This essay is concerned with Graham Bird’s treatment, in The Revolutionary Kant, of Kant’s mathematical antinomies. On Bird’s interpretation, our error in these antinomies is to think that we can settle certain issues about the limits of physical reality by pure reason whereas in fact we cannot settle them at all. On the rival interpretation advocated in this essay, it is not true that we cannot settle these issues. Our error is to presuppose that the concept of the unconditioned has (...) application to physical reality. Once this presupposition has been abandoned, we can retrieve sound arguments from the antinomies, not indeed to demonstrate that the views originally being defended are correct, but to demonstrate that the views originally being attacked are incorrect. The essay concludes with some comments concerning how this disagreement relates to a broader disagreement about the best way to understand Kant. (shrink)

This volume presents a selection of the most important writings in the debate on the nature of meaning and reference which started one hundred years ago with Frege's classic essay "On Sense and Reference." Contributors include Bertrand Russell, P.F. Strawson, W.V. Quine, Donald Davidson, John McDowell, Michael Dummett, Hilary Putnam, Saul Kripke, David Wiggins, and Gareth Evans. The aim of this series is to bring together important recent writings in major areas of philosophical inquiry, selected from a wide variety of (...) sources, mostly periodicals, which may not be conveniently available to the university student or the general reader. (shrink)

It is argued that the use/mention distinction, if it is to be a clear-cut one, cannot have the significance that it is usually thought to have. For that significance attaches to the distinction between employing an expression in order to draw attention to, or to talk about, some aspect of the world, as determined by the expression’s meaning, and employing it in order to draw attention to, or to talk about, the expression itself—and this distinction is not a clear-cut one. (...) In the final section of the essay this argument is extended to cast doubt on a rather glib appeal to the use/mention distinction that is frequently made in the philosophy of language. (shrink)

The aim of this essay is to characterize the issue whether tense is real. Roughly, this is the issue whether, given any tensed representation, its tense corresponds in some suitably direct way to some feature of reality. The task is to make this less rough. Eight characterizations of the issue are considered and rejected, before one is endorsed. On this characterization, the unreality of tense is equivalent to the unity of temporal reality. The issue whether tense is real, so characterized, (...) is then related to Kant’s deduction of the categories in his Critique of Pure Reason. It is argued that Kant’s deduction does not provide the argument for the unreality of tense that it may appear to. The conclusion drawn at the end of the essay is that the unreality of tense cannot be argued for—not because tense is real, but because, even if it is unreal, its unreality is basic. (shrink)